Methylated Complex 90 Capsules

Methylated Complex is particularly beneficial for those requiring support for homocysteine metabolism. Homocysteine is a natural compound found in the body that, if elevated, could affect cardiovascular health.

Formerly Methyl Complex, Methylated Complex provides high-quality, bioactive forms of key B vitamins and betaine to support your body’s natural methylation processes; crucial for DNA repair, detoxification, and brain chemistry. This expertly formulated supplement includes methylcobalamin (B12), 5-MTHF folate, and P-5-P (B6), all in forms the body can immediately use. With added betaine for homocysteine regulation, it’s the perfect choice for those needing support with mood, energy, heart health, or stress-related nutrient depletion.

Methylated Complex features folate as 5-methyl tetrahydrofolate, the biologically active, “body ready” form of folate. Folate may be the most significant vitamin in supporting homocysteine balance. It is crucial biologically, for the re-methylation of homocysteine into methionine.

Methylated Complex also contains vitamins B6 as Pyridoxal-5-Phosphate, also known as P-5-P. Pyridoxal-5-Phosphate is vitamin B6 in its most biologically active form. Vitamin B6 has many important functions in the body and works closely with the other B vitamins and other nutrients. P-5-P is biologically essential for over 160 vital enzyme processes in our body!

Both vitamin B6 and P-5-P are components of the amino transferase enzymes and are necessary for the trans-sulphuration of homocysteine. This is a complex description of how vitamin B6 contributes to homocysteine metabolism.

Methylated Complex also contains vitamin B12 as methylcobalamin, which is the activated, body-ready form of vitamin B12. The importance of adequate levels of B12 cannot be understated. B12 is involved in several important functions in the body, within every single cell! Vitamin B12 is also essential for normal homocysteine metabolism. In the body, the re-methylation of homocysteine is dependent on adequate levels of vitamin B12.

Clinical studies have demonstrated that betaine (trimethylglycine) may help to balance homocysteine levels.

Just like the quality and the strength, the form of a nutrient has an impact on its efficacy too. For example, we choose to use the active and methylated forms of B vitamins that are ready to be used as soon as they are consumed and don't need to be converted by the body, which some people may struggle to do.

Methylation refers to a biochemical process that occurs in each cell of the body, involving the transfer of a methyl group (one carbon atom and three hydrogen atoms) onto amino acids, proteins, enzymes, and DNA. This process is essential for a range of bodily functions, including gene expression, energy production, immune response, and the detoxification of heavy metals and other harmful substances. Proper methylation supports overall health and well-being.

Signs that you may benefit from methylation support include persistent fatigue, difficulty concentrating, or an unbalanced mood. Other signs might include high homocysteine levels, which can be detected via blood testing, and are often linked to cardiovascular issues, or poor detoxification.

You may wish to speak to your healthcare professional to see if methylation support, like Methylated Complex, is beneficial for you.

Certain individuals may require additional support with homocysteine balance due to various factors affecting methionine metabolism. Genetics, diet, and lifestyle factors, can influence the body's ability to effectively process homocysteine. For example, genetic variations in enzymes involved in homocysteine metabolism may impact the body's natural regulation.

Additionally, insufficient intake of essential nutrients like B vitamins, specifically B6, B12, and folate, can affect the conversion of homocysteine into other beneficial compounds, as can smoking and excessive alcohol consumption.

Our new label design has been introduced to help you to find a product that’s right for you, simplifying the way you navigate our range. The new labels provide you with more product information and better highlight the core benefit of each product. For example, you will see new health need colours and descriptions that make it easier to identify ranges and highlights the products main benefit.

Nutri Advanced is transitioning to the Metagenics brand to align more closely with our global family, who we joined in 2022. We have worked closely with Metagenics for decades with many of our products produced from their European Headquarters in Belgium. Metagenics is a global leader in the professional supplements market and is renowned for clinically proven, precision-crafted formulas to support your health. In 2024, they were voted the No. 1 Doctor Recommended Professional Supplement Brand in the US. They also held the No. 1 VMS position in Belgium for their Magnesium product, MetaRelax, and had the most prescribed probiotics brand among health professionals in Italy and Australia.

The change from Nutri Advanced to Metagenics will give you access to even more ground-breaking new product innovations and nutritional resources whilst maintaining our trusted formulations and excellent UK based customer service.